Another Way for Men to Control their Reproductive Strategy.

A male birth control pill may finally be around the corner

Almost sixty years since the FDA approved the pill for birth control in women, a male version may finally be on the horizon. Researchers have developed a prototype male pill that appears to be safe in a month-long trial.

From article, (Almost sixty years since the FDA approved the pill for birth control in women, a male version may finally be on the horizon. Researchers have developed a prototype male pill that appears to be safe in a month-long trial.

The prototype pill—dimethandrolone undecanoate (DMAU)—is somewhat similar to the combined female pill, which contains estrogen and a steroid hormone. Rather than estrogen, DMAU uses a male hormone like testosterone.

Currently available forms of testosterone can exit the body too quickly for use in a once-daily pill. The “undecanoate” in DMAU, however, is a long-chain fatty acid that can slow the drug’s journey out of the body, Page said.

Eighty-three men took various doses of DMAU or a placebo for a month. Researchers analyzed the men’s hormones and cholesterol with blood tests at the start and end of the study. They found testosterone and two hormones needed for the production of sperm were notably suppressed in men who took the highest dose of DMAU.

While some subjects on all doses experienced mild weight gain, DMAU appeared safe. All participants passed safety tests including liver and kidney health checks.

“Despite having low levels of circulating testosterone, very few subjects reported symptoms consistent with testosterone deficiency or excess,” Page said. There were no significant changes in mood or sexual function, but a minority of participants did experience decreased libido during the study. 

Page has high hopes for the results, calling them “unprecedented in the development of a prototype male pill.” Longer-term studies are the next step toward a once-daily male contraceptive pill, she said.)

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