Friday, January 12, 2018

Sometimes a Diet Pill is Better for a Patient, who can't lose the Weight Normally

Our climate is changing rapidly. It's time to talk about geoengineering.

Planet Earth is humankind's biggest experiment. From the moment we figured out how to use fire and altered the land through farming, humanity turned the planet into an immense, long-term experiment of what happens when we tinker with the types and quantities of gases in the atmosphere.

From article, (Nearly thirty years ago, at a lecture at the Woods Hole Oceanographic Institution in Massachusetts, an oceanographer named John Martin stood up and famously announced: “Give me half a tanker of iron, and I will give you an ice age.”Martin’s bold pronouncement kicked off a decade of research into one of the first geoengineering schemes that scientists considered potentially viable.

Called iron fertilization, Martin’s idea is fairly simple in principle. All it requires is dumping a layer of iron, likely in the form of greenish crystals of iron sulfate, on a broad swath of the ocean surface. The iron stimulates the growth of phytoplankton, minuscule marine plants that absorb carbon dioxide and release oxygen. In theory, if done on a massive scale, iron fertilization would remove a large portion of anthropogenic carbon dioxide from the atmosphere, proponents say.

Marine scientists have emphasized that, while large phytoplankton blooms do take up carbon dioxide while they’re alive, when they die, their tiny decomposing bodies attract bacteria. Dying phytoplankton gathered en masse can cause the digesting bacteria to use up all of the oxygen in the surrounding waters, creating a “dead zone” that can kill or sicken anything that swims into it.

These days, researchers are leaning more towards geoengineering techniques that mimic Earth’s natural processes. The leading method among geoengineering proponents is stratospheric aerosol injection, a process in which reflective particles are released into the upper atmosphere. If this method were to work as intended, the particles would reflect incoming light, reducing the overall greenhouse effect of the atmosphere. This method essentially mimics the output of volcanic eruptions, which have demonstrated a cooling effect on the planet in the past.

There are risks here, too, though. A recent modeling study in the journal Nature showed that stratospheric aerosol injections in the Northern hemisphere would slightly cool the region and could even decrease North Atlantic hurricanes. But it would also cause devastating droughts in sub-Saharan Africa. The opposite — releasing these particles in the atmosphere above the Southern hemisphere — would increase rainfall in sub-Saharan Africa but increase the number of tropical cyclones hitting the eastern United States. In both cases, this would occur because the regional jet stream would get stronger and shift towards its respective pole.

The only way to avoid this would be constant or regular injections — at the least, every six months, Haywood estimates  at high altitudes around the equator in order to make sure the particles would distribute evenly. This would require a near-global agreement by world governments, a consensus of everyone on the planet to alter the place we’ve always lived.

This is the real problem, according to those who oppose geoengineering: We would rather find a “quick fix” than do the hard work of cutting our dependence on fossil fuels. Yet those fixes don’t exactly work the way we think they do. We’re thinking about our planet the way some people think about losing weight; we would rather take diet pills and continue eating terribly, but in the end, we’ll end up working much harder than if we had just stuck with diet and exercise.)

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Me, "What isn't emphasised enough is that we need to take action now, to prevent global warming effects later. While these global cooling or reducing effects are considered extreme, So, will be our future weather. Sometimes, a diet pill is better for a patient who can not loose the weight normally but would gain from the affect."

Faster Growing trees, Means more fuel for Bio-Energy and Carbon Sequestration.

Flourishing faster: How to make trees grow bigger and quicker

Scientists at The University of Manchester have discovered a way to make trees grow bigger and faster, which could increase supplies of renewable resources and help trees cope with the effects of climate change. In the study, published in Current Biology, the team successfully manipulated two genes in poplar trees in order to make them grow larger and more quickly than usual.

From 2015...
From article, (Scientists at The University of Manchester have discovered a way to make trees grow bigger and faster, which could increase supplies of renewable resources and help trees cope with the effects of climate change.

In the study, published in Current Biology, the team successfully manipulated two genes in poplar trees in order to make them grow larger and more quickly than usual.

Professor Simon Turner from the Faculty of Life Sciences led the research: "The rate at which trees grow is determined by the rate of cell division in the stem. We have identified two genes that are able to drive cell division in the stem and so override the normal growth pattern.

"Although, this needs be tested in the field, this discovery paves the way for generating trees that grow more quickly and so will contribute to meeting the needs for increased plant biomass as a renewable source of biofuels, chemicals and materials while minimising further CO2 release into the atmosphere."

The genes, called PXY and CLE, control the growth of a tree trunk. When overexpressed, making them more active than in their normal state, the trees grew twice as fast as normal and were taller, wider and had more leaves.

As well as the potential to increase biomass supplies for the growing biofuel and industrial biotechnology sectors, the discovery could help plants deal with the environmental consequences of climate change.)


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Me, "So, what happened with this research?"



Forest Restoration will only cut Emissions if the Carbon dioxide is stored underground. What is also needed is faster Growing Trees.

With biomass energy, weighing forest restoration and carbon emissions

When state utility regulators held a workshop last month about increasing the use of forest biomass for power, one topic did not make it into the discussion: the emissions produced from burning small trees, branches and treetops hauled from Arizona's forests.



Compared to coal, burning biomass emits lower amounts of key pollutants like sulfur dioxide and nitrogen oxides, but it generally equals or surpasses coal in the amount of carbon dioxide it emits per unit of heat.
 Arizona already has one utility-scale biomass power plant in Snowflake, on the east side of the state.
The facility uses up woody biomass from 15,000 to 20,000 acres per year, Novo BioPower CEO Brad Worsley said. In addition to the fact that trees grow back, Worsley said his fuel source is renewable and carbon-neutral because it’s using carbon, stored in the tree, that is already part of the carbon cycle and would otherwise burn up or decay in tens or hundreds of years. Fossil fuels, on the other hand, are reintroducing carbon that has been buried for millions of years.
Worsley said that what he burns in his power plant is the bark, limbs and small trees that can’t be made into many other wood products that would sequester carbon, as Bahr had mentioned.
While his plant does burn forest material and produces emissions, it also helps make the forest less prone to catastrophic wildfires that would burn through, and emit, much more, Worsley said.
But Harmon said that math doesn’t work out if one thinks about a single forest. In a simplistic scenario, if half of the trees in a forest are harvested and burned for biomass energy and it takes two years for the forest to grow back to its original capacity to sequester carbon, its per-year sequestration average will be less than a forest where all of the trees remained for all three years. Even though the trees grew back, there was a period when carbon sequestration was reduced, bringing down the average.
And in thinning projects where the idea is to reduce tree density in the long run, total carbon storage will permanently be lower than pre-thinning, also challenging the notion of carbon neutrality, he said.)

Me, "What is not considered in this article is to Sequester the Carbon Dioxide, from burning the trees, in this plant, underground, and not allow it to enter the atmosphere to begin with. Also, it might make sense to genetically engineer faster growing trees to plant and take up the slack for cut down trees. 
If Grass can grow tall enough on a home lawn to need to be cut back every two weeks, by lawnmower,  I can't see an obstacle to bio-engineering faster growing trees. Faster growing trees benefit loggers, and benefit forests that have been over cut. The trees would grow back to take up the space of severely depleted forests. 
  Right now, tree farmers plant christmas trees and harvest them when they get big enough. This can take a few years. So, it is not uncommon to see rows of farms with different size, age, trees. In the future loggers may become like these farmers. They plant a bioengineered fast growing forest on a farm and by the end of the growing season have big trees to cut down mill or burn."

Giving back to the Community by Mining Bit Coins

How this greenhouse and fish farm operation is fuelled by bitcoin mining | CBC News

More than 30 computers sit on the second floor of a former car museum west of Winnipeg, quietly working to mine bitcoin. The heat generated by those computers, which are verifying bitcoin transactions by solving cryptographic puzzles, helps warm nearby plants in a makeshift greenhouse.
From article, (More than 30 computers sit on the second floor of a former car museum west of Winnipeg, quietly working to mine bitcoin. 
The heat generated by those computers, which are verifying bitcoin transactions by solving cryptographic puzzles, helps warm nearby plants in a makeshift greenhouse.
To water the trays filled with lettuce, basil and sprouted barley fodder, Bruce Hardy, the owner of this 20,000-square-foot building in the Rural Municipality of St. Francois Xavier, clicks a button.
A pump waters the plants with waste water from tanks located on the first floor in which around 800 Arctic Char swim and breed. The waste water from the tanks is rich in nitrates, a great fertilizer for the plants upstairs.
 The company is still experimenting with using the heat from bitcoin mining in different ways. Right now, about one-quarter of the second floor is filled with computers and plants, but Hardy hopes to eventually fill the space.
Starting the operation would have been a lot more difficult without the bitcoin cash, said Hardy. The price of a bitcoin is hovering around $19,000 Cdn.  
"The revenue from those bitcoins has helped me to keep staff on, it's helped me create these displays so we can show people what we're doing in agriculture innovation," said Hardy.
His company's goal is to use technology to create sustainable food systems.
Hardy runs his own software company and has been in the bitcoin mining business for two years. He used to pay for air conditioning to cool off the computers, but quickly realized there was a better use for the heat.
​"When bitcoin came, they were an excellent proxy for what a server could do in terms of emulating heat, and whether we could use that heat for agricultural purposes," he said.​)



Diabetics Who suffer from pain, tingling, and numbness in the Hands and Feet may now have a Drug to fight these symptoms.

Discovery Could Lead to New Therapies for Diabetics

An enzyme previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy also plays a role in peripheral neuropathy caused by diabetes. The significance of the identification of a common molecular mechanism is that many more patients could potentially benefit from drugs that target this mechanism.



From article, (Peripheral neuropathy is a potentially disabling condition affecting up to 40 million Americans that causes, pain, tingling and numbness in the hands and feet. Treatments exist for alleviating pain, but the development of treatments to prevent or reverse nerve degeneration has been stalled by a lack of understanding of the underlying mechanisms.

"This finding means that the drug candidates we have identified to treat chemotherapy-induced peripheral neuropathy could potentially be used to treat peripheral neuropathy that is caused by diabetes as well," Rieger said.

New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy also plays a role in peripheral neuropathy caused by diabetes.

The significance of the identification of a common molecular mechanism is that many more patients could potentially benefit from drugs that target this mechanism. In earlier research, Rieger identified two drug candidates for the treatment of chemotherapy-induced peripheral neuropathy that she is seeking to move into human clinical trials.

"Peripheral neuropathy is a major and growing health problem," said Kevin Strange, Ph.D., president of the MDI Biological Laboratory. "The identification of the mechanism underlying glucose-induced peripheral neuropathy means that millions of patients could potentially benefit from the development of drugs that influence this pathway."

In previous research in zebrafish, Rieger identified two compounds that prevent and reverse peripheral neuropathy caused by exposure to Taxol, or paclitaxel, a common cancer chemotherapy agent. The compounds are the subject of a pending patent originally filed in 2016 by the MDI Biological Laboratory.

The recent study, published in theJournal of Diabetes and Its Complications, tested the effectiveness of one of these compounds in preventing glucose-induced peripheral neuropathy. The study found the compound to be effective in zebrafish and in mice, which are mammals like humans.

"The fact that this compound works in two such disparate species makes it more likely it will work in humans too," Rieger noted.)





Slowing and Reversing Cancer Growth. Even for Some who do not have Viable Treatment Options.

New hope for cancer patients

There is new hope for patients suffering from various lines of cancer, according to a peer-reviewed article published Friday in the journal Scientific Reports, from the publisher of Nature. According to the article, placenta-derived PLX cells exhibit a strong inhibitory effect on various lines of breast, colorectal, kidney, liver, lung, muscle and skin cancers.

From article, (“We believe the findings show promise for the utilization of our induced PLX cells in slowing and reversing the growth of cancer cells, particularly for some cancers that don’t have viable treatment options,” said Zami Aberman, Pluristem chairman and co-CEO.

Over the last 10 years, Pluristem has reported robust clinical data in multiple indications for its patented PLX cells, and is entering late-stage trials in several indications. The PLX cell products release a range of therapeutic proteins in response to inflammation, stopped-up blood vessels (ischemia), muscle trauma, blood disorders and radiation damage. Pluristem’s cells can be administered off-the-shelf without tissue matching.

Based on this recent research, Pluristem conducted an additional pre-clinical study of female mice induced with human triple negative breast cancer, commonly known as TNBC. This form of breast cancer does not respond to standard hormonal therapy and is instead treated with a combination of surgery, radiation therapy and chemotherapy. The prognosis for patients with TNBC is poor.

 The new study showed that weekly intramuscular injections of induced PLX cells reduced the size of the of the tumors, and in 30 percent of the treated mice led to complete tumor remission.

Aberman said these latest findings may open new possibilities in the field of oncology to treat solid tumors and may also offer new paths to help millions of patients around the world.)



Simulating the weather and seasons of Earth on the Moon, Mars, etc, colonies, really isn't that hard, and can have emotional benefits for astronauts.

hWe talked to astronaut Scott Kelly about the psychological challenges of going to Mars

Living in space is even more challenging than it seems. Microgravity affects your body in weird ways, the high-risk environment can create high-stress situations, and you don't have the comforts of your daily life on Earth: no showers, no fresh food, no fresh air, and no loved ones to go back to at the end of your work day.


From article, (Living in space is even more challenging than it seems. Microgravity affects your body in weird ways, the high-risk environment can create high-stress situations, and you don’t have the comforts of your daily life on Earth: no showers, no fresh food, no fresh air, and no loved ones to go back to at the end of your work day.

Despite the[se] physical and psychological challenges, [Astronaut Scott] Kelly said he’d volunteer for a mission to the Red Planet — with one caveat: he has to have a return ticket to Earth. "Having spent a year on the space station," he says, "I can’t imagine spending the rest of my life in an environment like that, where you can’t go out and get fresh air.")

For More Info Me, "Which is why when we set up Moon, Mars, etc., bases we need to simulate weather conditions on Earth in these colonies. It sounds complex but it really isn't. At some point these bases will get big enough to hold a small park, and in this park you can simulate weather and seasons. 
You can have artificial wind (Hidden electrical Fans) giving uneven blowing air over the trees and grasses. 
You can simulate rain by either intermittent sprinkler systems in the roof raining down on the park at uneven timings. Obviously, you can stand in it or sit under a small gazebo as it rains. 
You can simulate night and day cycles by directing sunlight, light from the sun outdoors, indoors through fiber optic cables and shutting it off to simulate night. (You'd have street lights to see where your going.) 
You can even simulate snow, as we already use this technology at ski resorts.  
If you want the seasons? You pick a place on Earth that you want your base to sync Earth seasons too. Everyday these local Earth conditions are fed to the base park's weather and seasons computer, which makes corrections in conditions.
 You change the park temperature throughout the year and you change the light levels to make the parks trees shed their leaves and go into hibernation and then come back during spring.
As the bases get bigger you can build out parks and at some point they get so big you don't feel like your in a confined space anymore. You feel like your back on Earth.
There are a lot of ways to make astronauts feel at home, emotionally, and physically, on the Moon, Mars and beyond with just plain old technology. And, giving them a place to go to be one with nature.

Everything I have just stated is in one way or another simulated at theme parks like Disney, or used at ski resorts." 

Boca Chica now gets SpaceX construction workers' Attention.

SpaceX could begin testing its Mars rocket in Texas by late 2018, early 2019

On the heels of a successful wet dress rehearsal for Falcon Heavy, SpaceX's President and COO Gwynne Shotwell spoke briefly about SpaceX for an aerospace conference located at Texas' Academy of Medicine, Engineering & Science. Ars Technica's senior spaceflight editor Eric Berger was in attendance and provided a rough outline of live tweets during the first ...


 From article, (On the heels of a successful wet dress rehearsal for Falcon Heavy, SpaceX’s President and COO Gwynne Shotwell spoke briefly about SpaceX for an aerospace conference located at Texas’ Academy of Medicine, Engineering & Science. Ars Technica’s senior spaceflight editor Eric Berger was in attendance and provided a rough outline of live tweets during the first group of presentations.
While the phrasing cannot provide absolute confirmation, Berger summarized a statement by Shotwell suggesting that SpaceX’s Boca Chica, Texas launch site, currently in the early stages of construction, could be ready to host “vehicle tests” as soon as late 2018, early 2019. At this point in time, based on comments from Shotwell and CEO Elon Musk, it can be reasonably assumed that SpaceX’s Texas launch facilities will be dedicated mainly to the company’s interplanetary colonization efforts, and will probably be tailored to support the testing and eventual launches of BFR/BFS.
After nine months of earnest construction and rehabilitation, SpaceX’s LC-40 pad was recently reactivated and has since supported two launches without any major hitches. At the same time, LC-39A in flux in order to support launches of SpaceX’s new Falcon Heavy rocket, the size of which required some concomitant upgrades to multiple ground systems. With both of those major tasks now effectively complete, SpaceX’s pad construction team is free to either refocus their efforts towards Boca Chica.

Originally announced as an additional Falcon launch facility in 2014, Boca Chica has remained relatively dormant over the last three years, and it is truly exciting to see activity ramping up. There are admittedly significant barriers that will prevent SpaceX from effortlessly repurposing its Boca Chica pad for BFR, a much larger rocket. If SpaceX intends to do that, they will almost certainly need to pass a significantly updated FAA environmental impact review and account for any remediations that might be required. Still, that is a small ask for for Brownsville’s local government and Texas as a whole, both of which have clearly enjoyed and begun to benefit from SpaceX’s presence in the otherwise unknown area. SpaceX is unlikely to give up on Boca Chica in the near term, so long as Ms. Shotwell maintains her belief that it is effectively the perfect location for BFR launches. )