Friday, April 20, 2018

An Idea, for a Floating Solar Farms on LA Reservoirs, Would Produce Power for 3,190 Homes But Its Real Value Would Be To Protect Water From Evaporation.

LA councilman proposes floating solar panels on reservoirs

We've seen solar panels on rooftops and in large-scale solar farms. Now, Los Angeles City Councilman Mitch Englander is proposing that the city build floating solar grids on local reservoirs for energy. "This is a technology that is already being used in other countries from China and Japan," said Englander, of District 12.

From article, (We've seen solar panels on rooftops and in large-scale solar farms. Now, Los Angeles City Councilman Mitch Englander is proposing that the city build floating solar grids on local reservoirs for energy.

"This is a technology that is already being used in other countries from China and Japan," said Englander, of District 12. "The pilot that I'm proposing calls for an initial installation of 11.6 megawatts of solar power on our reservoirs, serving electrical needs for 3,190 homes per year."

He was joined by actors, students and clean energy activists at a news conference who feel L.A. is in a unique position because our weather and geography would support such a proposal.

"It's good for the environment, and it's good for your pocket book to do this, " said actor Ed Begley Jr., who has appeared in countless films and television shows.

The news conference was held at Lower Van Norman Reservoir in Sylmar, located just off Interstate 5. It is one of several proposed sites for the pilot project. At this location, the L.A. Department of Water and Power said the solar panels would float amid the millions of tiny black balls, known as "shade balls," that protect the reservoir's water quality.

"If we can protect water, protect water quality, protect evaporation and at the same time leverage the space for solar needs to help our plans for the future, we have a great opportunity," said LADWP Chief Operation Officer Marty Adams.

It also eliminates the cost of finding land for a large-scale solar panel farm. However, Englander couldn't tell ABC7 exactly how much this pilot program to put solar panels in a reservoir would cost the city.

"What we're looking at is creating some kind of public-private partnership with an opportunity for some vendors to get involved in a power purchase agreement where we're not actually spending any money, or very little out in front of it, and we're getting it all in return because we're generating our own power," said Englander.

He is delivering his proposal to the city council on Friday. If approved, he said the pilot program would take just a few months to complete.)

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Get Ready For More Falcon Heavy Launches.

SpaceX's Shotwell: Expect a 'couple more' Falcon Heavy launches this year

CLOSE COLORADO SPRINGS - The Space Coast can expect a "couple more" of the massively popular Falcon Heavy launches from Kennedy Space Center this year, SpaceX's president and chief operating officer said during a dinner event Thursday night. "We have a big year in front of us," Gwynne Shotwell said during a closing dinner at the 34th Space Symposium.

 From article, (The Space Coast can expect a "couple more" of the massively popular Falcon Heavy launches from Kennedy Space Center this year, SpaceX's president and chief operating officer said during a dinner event Thursday night.

"We have a big year in front of us," Gwynne Shotwell said during a closing dinner at the 34th Space Symposium. "We've got a couple more heavys to fly, which will be very exciting."

"For satellites this time – not cars," Shotwell said jokingly.

The first of those Falcon Heavy launches from pad 39A is expected this summer, when the 27-engine, three-core rocket will take an Air Force mission to orbit with NASA science spacecraft riding as secondary payloads. 

And the second mission will take Saudi Arabia's Arabsat-6A communications satellite, which was built in Colorado, to orbit sometime in late 2018.SpaceX has not commented on booster recovery details surrounding those missions and whether or not Cape Canaveral and / or drone ship landings will be involved. The company could also opt to expend at least one of the boosters, too.

On SpaceX's workhorse vehicle, Shotwell said the company has "a ton of Falcon 9s to fly" and a "bunch more reflights to do," referring to launching previously flown versions of the booster.

Early next month, SpaceX is also planning to debut the "Block V" version of its Falcon 9 rocket, which is designed for greater reusability. The mission will take Bangladesh’s first geostationary satellite, labeled Bangabandhu-1, to orbit from KSC’s pad 39A.)

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Thursday, April 19, 2018

More Details on VW Fast Charging Stations in the U.S.

Ride the Lightning: Electric Car Charging Technology Is About to Surge Past Tesla's Superchargers

By the end of 2019, new systems could leave Elon Musk's high-speed car charging network in the dust. Tesla Tesla's Supercharger network has long been the gold standard for electric vehicle charging systems. The company's hefty investment into charging support for its own customers-the company's proprietary plugs mean no other EVs can charge there-has been planned out to ensure Tesla owners can use their vehicles as they please without worrying about whether they're going to run dry on a road trip.

 From article, (Tesla’s Supercharger network has long been the gold standard for electric vehicle charging systems. The company’s hefty investment into charging support for its own customers—the company's proprietary plugs mean no other EVs can charge there—has been planned out to ensure Tesla owners can use their vehicles as they please without worrying about whether they’re going to run dry on a road trip. So far, it’s been the envy of EV owners everywhere, who haven’t had the same breadth of access or the same charging speed. (Tesla Superchargers deliver between 120–140 kilowatts of power, enough to fully charge a Model S with a 90-kWh battery in just over an hour, or provide 170 miles of range in 30 minutes.) 

The Supercharger stands aren't just convenient, though. The company’s roughly 400 stations in North America—1,200 globally—are clean, bright, and kinda cool. The most fabulous: A station midway between Los Angeles and San Francisco, in Kettleman City, that opened in last fall with 40 stalls, solar roofs, and a waiting area with a coffee bar and play area for the kids. It feels more like the Virgin Atlantic business class lounge at Heathrow than a roadside rest stop.

Tesla's golden-boy status in the EV charging community, however, is about to change. By the end of 2019, there could be another 1,000 charging stations around the country that offer far faster charging than Elon Musk's vaunted Supercharger network. Both Porsche and Electrify America—a wholly-owned subsidiary of the Volkswagen Group, which, of course, owns Porsche as well—have announced in recent days plans to construct roughly 500 DC fast-charge stations each. The systems will provide up to 350 kW of power for cars capable of charging that fast, which translate to about 20 miles of range for every minute of charge. That comes out to 300 miles of range in just 15 minutes. At those speeds, who’s going to need a lounge?

Porsche also hasn’t disclosed its per-station costs, but Electrify America told The Drive that its own “Cycle 1” infrastructure investment for 484 DC fast charge sites on highways and metro areas totals $370 million. (The Electrify America effort is just part of a 10-year, $2 billion investment to be made by Volkswagen Group of America in EV infrastructure, education, and access, and reflects a relationship with the EPA and the California Air Resources Board.) That number also includes 600 workplace and apartment/condo sites with slower Level 2 charging—DC fast charging is generally considered Level 3—but even with that generously factored in, each fast-charge station could cost in the neighborhood of $500,000 or more.

In terms of speeding up the adoption of electric cars, however, the payoff could be huge, as the system could provide the easy access and low wait times consumers demand. The stations will provide between 200 and 920 volts at 350 amps of current, an Electrify America spokesman said, which translates to between 50 kW and 350 kW of capability. This will cover a wide range of EVs, including current lower-range models that use AC hookups. The real technological breakthrough on the high-speed end rests in the charge cable, which is lighter and thinner than existing equivalents thanks to a liquid-cooling system that reduces the heat load passing through the cables in high-amperage use. Reducing these temperatures allows them to provide higher electrical current—that 350-amp maximum—through cables that are much thinner and easier to manage than the thick cables found on Superchargers. The stations will also be easy to use, standing up to eight feet high for better cable reach and with a 15-inch color touchscreens to operate the station and provide payment or account info.)



Puerto Rico can't catch a break, Suffers from Another Island Wide Power Blackout. However, For Hundreds, Tesla Energy Projects Kept The Power On

Tesla Powerwalls and Powerpacks keep the lights on at 662 locations in Puerto Rico during island-wide blackout, says Elon Musk

Almost 1 million ratepayers of the Puerto Rican Electric Power Authority on the island of Puerto Rico were reportedly without power today during an island-wide blackout. But a few hundred locations with Tesla Energy storage systems were able to keep the lights on, according to CEO Elon Musk.
From article, (Almost 1 million ratepayers of the Puerto Rican Electric Power Authority on the island of Puerto Rico were reportedly without power today during an island-wide blackout.
But a few hundred locations with Tesla Energy storage systems were able to keep the lights on, according to CEO Elon Musk.

After Puerto Rico was ravaged by hurricanes last year, most of the island’s population lost power for an extended period of time as the grid was badly damaged.

While power slowly came back online over the last few months, they still have been having issues and today, the entire power grid went down again for virtually everyone on the Puerto Rican Electric Power grid.

The cause is still unclear and being investigated.

 Only people with energy storage systems were able to keep the lights on, including Tesla Energy customers.

Tesla ramped up its effort to help Puerto Rico get a more robust grid after it was destroyed by hurricanes. They quickly started shipping Powerwalls, their home energy storage solution, and we reported that they started shipping Powerpacks, their bigger commercial and utility-scale battery packs.

Now Tesla CEO Elon Musk says that it added up to 662 locations that were able to keep power during the blackout and that they are trying to add hundreds more.

As we previously reported, some of those locations include very critical services.

Furthermore, the automaker’s energy division also deployed a solar+battery system at a hospital in Puerto Rico.

Tesla shipped a few hundred more Powerwalls to Puerto Rico and sent technicians from all over the US to install them.

According to Musk, the effort resulted in 662 projects and there are more underway.)

Long Island To Get New Artificial Reefs To Help The Fishing Industry.

Recycled TZB Materials To Become Artificial Reefs

TARRYTOWN, NY - So the Tappan Zee Bridge is being torn down now that the Gov. Mario M. Cuomo Bridge is open for traffic. Were you wondering what was going to happen to all of that de-construction material? Well, Gov.

 From article, (Long Island will soon be the home of the largest expansion of artificial reefs in New York history, Cuomo said, the reefs will be comprised of cleaned and recycled materials from the TZB, as well as old tug boats, barges and scows.
The material will be used to build six artificial reefs off the Long Island coast.
"The sustainability and health of New York's marine resources is critical to communities along our shores, and by constructing these reef habitats, we are investing in a stronger more diverse marine ecosystem," Cuomo said. "As the largest artificial reef construction program in state history, these efforts will increase New York's marine biodiversity, provide new habitats for a variety of coral and fish, and support a growing tourism industry that brings thousands of anglers and travelers to Long Island's pristine waters every year."
Recycled materials from the Department of Transportation, Canal Corporation and the Thruway Authority will be used to develop the artificial reef sites and increase the biodiversity of these habitats for a variety of fish and lobsters. Construction of New York's first artificial reef dates back to 1949, and this latest initiative marks the state's first coordinated effort to stimulate the full environmental and economic benefits of artificial reefs.)

Self-Driving Cars Like, Teslas, and Waymos, Generate a Lot of Driving Data, That is Used to Make Their Self-Driving Safer. But, What Will Make People Accept Them As Safe?

How Tesla and Waymo are tackling a major problem for self-driving cars: data

There's a race happening right now that stretches from Silicon Valley to Detroit and back: who can make a self-driving car that behaves better than a human driver? It's a far harder task than it sounded even a few years ago because human drivers know a lot - not just about their cars but about how people behave on the road when they're behind the wheel.
From article, (There’s a race happening right now that stretches from Silicon Valley to Detroit and back: who can make a self-driving car that behaves better than a human driver? It’s a far harder task than it sounded even a few years ago because human drivers know a lot — not just about their cars but about how people behave on the road when they’re behind the wheel. To reach that same kind of understanding, computerized cars need lots of data. And the two companies with the most data right now are Tesla and Waymo.
Both Tesla and Waymo are attempting to collect and process enough data to create a car that can drive itself. And they’re approaching those problems in very different ways. Tesla is taking advantage of the hundreds of thousands of cars it has on the road by collecting real-world data about how those vehicles perform (and how they might perform) with Autopilot, its current semi-autonomous system. Waymo, which started as Google’s self-driving car project, uses powerful computer simulations and feeds what it learns from those into a smaller real-world fleet.
It’s possible — and proponents certainly claim — that self-driving technology would lower the number of yearly deaths in the US that result from car crashes, a staggering 40,000 people. But there’s also a huge financial incentive to apply all this data-driven tech to the road as quickly as possible. Intel believes autonomous vehicles could generate $800 billion per year in revenue in 2030 and $7 trillion per year by 2050. Last summer, Morgan Stanley analyst Adam Jonas said in a note that data might be more valuable to Tesla than something like the Model 3. “There’s only one market big enough to propel the stock’s value to the levels of Elon Musk’s aspirations: that of miles, data and content,” he wrote in June.
 Tesla is developing towards autonomy by using customer-owned cars to gather that all-important data. The company has hundreds of thousands of customers, many of whom use Autopilot on streets around the world every day, and Tesla — according to its privacy policy— collects information about how well the feature performs. It’s a familiar strategy for anyone who’s followed another of Elon Musk’s companies: SpaceX. Musk has quietly tested equipment on real rocket launches and even sold some of the company’s test launches.

It’s hard to pin down exactly how many miles of data Tesla’s gotten from Autopilot because the company doesn’t make many public statements about it. In 2016, the then-head of Autopilot told a conference crowd at MIT that Tesla had logged 780 million miles of data, with 100 million of those miles coming while Autopilot was “in at least partial control” according to IEEE Spectrum. Later that summer, Musk said that Tesla was collecting “just over 3 million miles [of data] per day.” As of last July, though, the total number of fleet miles driven had jumped to 5 billion. As Tesla sells more cars, the amount of data that can be collected increases exponentially.
Waymo is constrained by the fact that it is only gathering real-world data via a fleet of about 500 to 600 self-driving Pacifica minivans. Tesla has over 300,000 vehicles on the road around the world, and those cars are navigating far more diverse settings than Waymo — which is currently only in Texas, California, Michigan, Arizona, and Georgia. But Tesla is only learning from those real-world miles because even when Autopilot is engaged, the current version is only semi-autonomous.

This balance will also change. Waymo plans to add “thousands” more Chrysler minivans are to its fleet starting at the end of this year. And it recently announced a partnership with Jaguar Land Rover to develop a fully self-driving version of the all-electric I-Pace SUV from the ground up. Waymo says it will add up to 20,000 of these to its fleet in the coming years, and it will be able to handle a volume of 1 million trips per day once all those cars are on the road.

Not only are these two companies collecting data at different scales, they’re also collecting different data. Waymo’s self-driving minivans use three different types of LIDAR sensors, five radar sensors, and eight cameras. Tesla’s cars are also heavily kitted out: eight cameras, 12 ultrasonic sensors, and one forward-facing radar.
But Tesla doesn’t use LIDAR. LIDAR is a lot like radar, but instead of radio waves, it sends out millions of laser light signals per second and measures how long it takes for them to bounce back. This makes it possible to create a very high-resolution picture of a car’s surroundings, and in all directions, if it’s placed in the right spot (like the top of a car). It maintains this precision even in the dark since the sensors are their own light source. That’s important because cameras are worse in the dark, and radar and ultrasound aren’t as precise.
LIDAR can be expensive and bulky, and it also involves moving mechanical parts (for now, at least). Musk recently called the technology a “crutch,” and argued that while it makes things easier in the short term, companies will have to master camera-based systems to keep costs down.
If Tesla can develop autonomous cars without that tech, Keeney says that would be a huge advantage. “It’s a riskier strategy but it could pay off for them in the end,” she explains. “If Tesla solves [self-driving cars without LIDAR], everyone else is going to be kicking themselves.”
Kalra has co-authored a number of studies for RAND about self-driving technology, including one in 2016 that tried to determine how many real-world miles would need to be driven to prove that autonomous cars are safer than humans. 
Kalra and co-author Susan M. Paddock came to the conclusion that self-driving cars will need to be driven “hundreds of millions of miles and sometimes hundreds of billions of miles” to make any statistically reliable claims about safety. Because of this, they wrote, companies need to find other ways to demonstrate safety and reliability.
When it comes time for these companies to prove to regulators or customers that they’ve developed fully self-driving tech, the most likely metric that will be used to judge whether a company has developed a full-stop fully self-driving car is whether or not they’re as safe or safer than human driving. How to define that — the rate of crashes per X miles, injuries per X miles, or even deaths per X miles — is another question.
As Kalra and Paddock point out in their study, this will be hard to prove in real-world terms. But Kalra thinks it can’t be proven by simulation alone — at least not without a more thorough and open understanding of the quality and rate of data being collected. “We’re probably going to see this technology deployed before we have conclusive evidence about how safe it is,” she says. “This is the rub. We can’t prove how safe self-driving cars are until we all decide to use them.”

Wednesday, April 18, 2018

Building an Air Taxi Service Requires, Roof, Take Off and Landing Space, Hangers, and Fast Elevators, says Volocopter, Which Are All Doable

Volocopter envisions "air taxi" stations that can handle 10,000 passengers a day

If you want to be taken seriously in the "flying car" business, you need a solid infrastructure plan. It's not enough to just have a cool-looking aircraft that can take off and land vertically. You also need a citywide system of landing pads, charging stations, and passenger loading and unloading areas.

 From article, (If you want to be taken seriously in the “flying car” business, you need a solid infrastructure plan. It’s not enough to just have a cool-looking aircraft that can take off and land vertically. You also need a citywide system of landing pads, charging stations, and passenger loading and unloading areas. Uber is working on its own infrastructure plan, and now German startup Volocopter is ready to show off its own vision for a fully formed urban “air taxi” system, coming to a city near you.

Today, the company unveiled its vision for a network of rooftop “Volo-ports” where up to 1,000 passengers could board and disembark their own personal “flying taxi” every hour. That translates to 10,000 passengers per station per day, the company claims. These stations would include elaborate systems of conveyor belts, swappable battery packs, and elevators leading to vast charging ports — all designed to move the largest number of passengers possible while also ensuring its fleet of short-range aircraft are fully charged and ready to go.
Volocopter’s idea for a citywide air taxi system is clearly very ambitious. The company envisions building circular launchpads that jut out from the top floors of skyscrapers, from which Volocopter’s 18-rotor 2X electric aircraft could take off and land.
After landing, these vertical takeoff and landing (VTOL) aircraft would be moved via conveyor belt to an indoor hanger, where passengers can disembark, and batteries are swapped out by robots for freshly charged ones. Then, the aircraft are transferred via elevator to a parking garage of sorts on the floor below, where maintenance work can be done before the vehicles are deployed for more passenger-transporting.
Zosel said Volocopter hopes to have a prototype station in place sometime in the next year, but acknowledged it will take up to 10 years before a full, citywide system can be put in place. The cost of these elaborate stations would likely be spread out over a number of partners, including real estate groups, charging station operators, ride-hailing companies, and Volocopter itself.
The company has demonstrated the 2X’s flight capabilities in GermanyDubai (where the company is most likely to first launch its aerial taxi service), and more recently at CES in Las Vegas, where it announced a partnership with Intel.)


New Website, for Ireland Citizens, to Provide information on EVs, So As to Help Educate, and Facilitate Buying.

Electric cars about to become 'the new normal' in Ireland

The use of the electric vehicle (EV) on Irish roads is about to become "the new normal for people in their everyday lives" and "no longer just a progressive, environmental fad". That was the prediction of Jim Gannon, chief executive of the Sustainable Energy Authority of Ireland (SEAI), following the announcement of a public engagement campaign on EVs funded by the Government.

  
From article, (The use of the electric vehicle (EV) on Irish roads is about to become “the new normal for people in their everyday lives” and “no longer just a progressive, environmental fad”.
That was the prediction of Jim Gannon, chief executive of the Sustainable Energy Authority of Ireland (SEAI), following the announcement of a public engagement campaign on EVs funded by the Government.
There were 3,800 electric vehicles (EVs) on Irish roads by the end of 2017 but registrations of new and imported EVs are currently up by 40 per cent compared to same period last year.
He was speaking in Dublin’s RDS on Wednesday when the first phase of the SEAI campaign was unveiled – a single website allowing drivers to compare almost 40 different EV models now available in Ireland.
It also outlines how to access grants available to motorists and businesses – and helps motorists arrange for a test drive at their local dealer. It can be accessed at www.DrivingElectric.ieSEAI chair Julie O’Neill said: “At present, electric vehicles make up less than 1 per cent of the vehicle fleet in Ireland. We understand people’s concerns about driving electric, so the aim of this campaign is to dispel any of the myths around EVs, such as range, cost and charging, and to demonstrate that electric vehicles are for everyone.”
She added: “In 15 to 20 years’ time, the face of driving electric in Ireland will have changed completely from what we know now and the new website was a critical building block in that transition.”)

VW To Build Massive Electric Charging Network to Take On Tesla.

VW vows to build massive electric car charging network across US

Volkswagen wants to sell more electric cars in the US, but to do that, it needs to spend millions of dollars on building out the country's underdeveloped charging infrastructure. Toward that end, the auto giant's subsidiary, Electrify America, announced today that it plans to install EV charging stations at more than 100 Walmarts in 34 states by mid-2019.

From article, (Volkswagen wants to sell more electric cars in the US, but to do that, it needs to spend millions of dollars on building out the country’s underdeveloped charging infrastructure. Toward that end, the auto giant’s subsidiary, Electrify America, announced today that it plans to install EV charging stations at more than 100 Walmarts in 34 states by mid-2019. The announcement came a few days after Porsche, which is owned by VW Group, hinted at plans to build 500 of its own EV charging stations in the US.
The Walmart charging stations are part of a broader Electrify America project to install 2,000 chargers at nearly 500 charging stations across the country by June 2019. “EV owners need a convenient, reliable and fast turnaround in recharging their vehicles,” said Mark McNabb, president and CEO of Electrify America, in a statement. “Walmart is the perfect partner for Electrify America to bring electric charging services to EV owners who value their time.”

 Meanwhile, Klaus Zellmer, CEO of Porsche Cars North America, told Automotive Newsthat the performance brand would install at least 500 fast chargers at dealerships and highway locations across the US by the end of 2019. “If you want to buy that car, you want to know what happens if I go skiing and go further than 300 miles,” Zellmer said. “What do I do? So we need to have answers for that.”

Taken together, it represents a multimillion-dollar commitment by the German auto giant to blanket the US in charging stations, in the hopes of luring more American consumers to by its zero-emission vehicles. Another way of looking at it is that VW is taking a page from the playbook of Tesla, which has installed 1,210 of its Supercharger stations across the globe since 2012. It realizes that to persuade more American car buyers to consider going electric, it must first commit to a fully built charging network to help reduce range anxiety.)

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Changing a Gene in People Who Have Beta Thalassemia or Other Blood Disorders Works Wonders.

Gene therapy helps patients avoid blood transfusion

Even though it rarely affected her dance lessons, she also remembers being sick -- very sick. Sihanath, now 22, was diagnosed as a young child with the genetic blood disorder beta thalassemia. She was treated with occasional blood transfusions, which became monthly when she turned 14.

From article, (Beta thalassemia is an inherited blood disorder caused when the body doesn't make enough of a protein called hemoglobin, an important part of your red blood cells. It's found around the world, occurring most frequently in people from Mediterranean countries, North Africa, the Middle East, India, Central Asia and Southeast Asia. The total incidence of symptomatic cases each year is estimated to be about 1 in 100,000 people throughout the world.
In general, thalassemia can be well-managed with blood transfusions and chelation therapy which removes excess iron from the body with drugs, according to the US Centers for Disease Control and Prevention. Most people with severe anemia from thalassemia require red blood cell transfusions every two to three weeks.
The new study suggests a way to cut the need for those transfusions. It involved two trials with 22 patients total, 12 to 35 years old, with transfusion-dependent beta thalassemia. Transfusion dependence was defined in the study as having to receive at least eight transfusions per year, or at least 100 milliliters per kilogram of body weight of red blood cells per year, in the two years prior to enrolling in the study.
The two trials were to evaluate the safety and efficacy of a gene therapy for beta thalassemiausing LentiGlobin, an investigational therapy by Bluebird Bio. It works by inserting a functional human beta hemoglobin gene into a patient's own stem cells outside the body and then transplanting those modified cells back into the patient's blood stream.

One of the trials in the study, called HGB-204, included 18 patients and was conducted at six sites around the world: four in the United States, one in Australia and one in Thailand. The other trial, HGB-205, included four patients and was conducted at Necker Children's Hospital in Paris.

In all of the patients, their own stem cells were harvested in a process involving the use of the drugs filgrastim and plerixafor, which move stem cells from the bone marrow to the bloodstream. Once the stem cells were collected, they were sent to a lab where they were transduced with LentiGlobin, which inserted that healthy beta-globin gene.
To prepare their bodies for the gene therapy, patients then underwent four days of the chemotherapy drug busulfan intravenously. Next, their modified stem cells were transplanted back into their bodies. After transplantation, they were monitored and followed up with during a period ranging from 15 to 42 months.
The researchers found that, "of those 22 patients, 15 of those patients became transfusion-independent, which meant that they were not transfused for a minimum of a one-year period," Thompson said. "For some, now it's been even much longer than a one-year period."
The researchers also found no serious adverse side effects related to the gene therapy and no significant unexpected safety issues.
"The side effects that were seen in these two clinical trials are consistent with what we expect from a transplant of any kind that uses chemotherapy," Thompson said.
There were five mild adverse effects in the HGB-204 trial and nine serious adverse events, including two episodes of veno-occlusive liver disease, attributed to the chemotherapy. In the HGB-205 trial, all four patients had adverse events related to the chemotherapy, such as mouth sores.
"There were no novel side effects identified that related either to the LentiGlobin vector or the gene therapy procedure itself," Thompson said. "We clearly want to watch for a much more extended period of time to be sure that there are no additional safety concerns."
In separate studies, some of the same researchers had tested the feasibility of transferring a healthy beta-globin gene into the cells of a beta thalassemia patient. In 2010, they first reported the successful use of the gene therapy for beta thalassemia in a patient.
Now, the findings in the new study appear to expand on that idea.
LentiGlobin is also being tested in patients with sickle cell disease, another group of inherited red blood cell disorders, which suggests that the therapy might have potential to be widely used for various diseases.
Dr. Douglas Higgs, professor of hematology and director of the MRC Haematology Unit at the University of Oxford in England, called the new study "important."
"Even though this is the best we can achieve at the moment, not all patients become free of transfusions and we still do not know the long-term effects of manipulating the genome of stem cells in this way," Higgs said in a statement.
"A major question hanging over this approach, which is hugely expensive, is whether this procedure, which involves killing off abnormal stem cells to replace them with modified stem cells, will ever become clinically possible in developing countries where the majority of these disorders of hemoglobin occur," he said.)



TESS

NASA's TESS Satellite Launches to Seek Out New Alien Worlds

NASA has a new planet hunter in the heavens. The agency's Transiting Exoplanet Survey Satellite (TESS) launched today (April 18) from Cape Canaveral Air Force Station in Florida, rising off the pad atop a SpaceX Falcon 9 rocket at 6:51 p.m. EDT (2251 GMT) and deploying into Earth orbit 49 minutes later.



From article, (NASA has a new planet hunter in the heavens.
The agency's Transiting Exoplanet Survey Satellite (TESS) launched today (April 18) from Cape Canaveral Air Force Station in Florida, rising off the pad atop a SpaceX Falcon 9 rocket at 6:51 p.m. EDT (2251 GMT) and deploying into Earth orbit 49 minutes later.
TESS will hunt for alien worlds around stars in the sun's neighborhood — planets that other missions can then study in detail. And the spacecraft will be incredibly prolific, if all goes according to plan. [NASA's TESS Exoplanet-Hunting Mission in Pictures]
"TESS is going to dramatically increase the number of planets that we have to study," TESS principal investigator George Ricker, of the Massachusetts Institute of Technology, said during a pre-launch briefing Sunday (April 15).
"It's going to more than double the number that have been seen and detected by Kepler," Ricker added, referring to NASA's Kepler space telescope, which has spotted 2,650 confirmed exoplanets to date —about 70 percent of all the worlds known beyond our solar system.
Like Kepler, TESS will find alien planets using the "transit method," noting the tiny brightness dips these worlds cause when they cross their host stars' faces. But there are some big differences between the missions.
During its prime mission from 2009 through 2013, Kepler stared continuously at a single patch of sky, monitoring about 150,000 stars simultaneously. (Kepler is now embarked on a different mission, called K2, during which it studies a variety of cosmic objects and phenomena, exoplanets among them. But the iconic telescope's days are numbered; it's almost out of fuel.) Most of these stars are far from the sun — from several hundred light-years to 1,000 light-years or more. 
But TESS will conduct a broad sky survey during its two-year prime mission, covering about 85 percent of the sky. The satellite will focus on the nearest and brightest stars, using its four cameras to look for worlds that may be close enough to be studied in depth by other instruments. 
Indeed, TESS will rely on a variety of other telescopes on the ground and in space to help determine which of its "candidates" are bona fide planets, and to characterize the newly discovered worlds. One such partner will be NASA's $8.8 billion James Webb Space Telescope, which is scheduled to launch in 2020. James Webb should be able to probe the atmospheres of at least a few TESS planets for oxygen, methane and other possible signs of life, NASA officials have said.
TESS also differs from Kepler in its orbit. Whereas Kepler loops around the sun, TESS will zoom around our planet, on a highly elliptical, 13.7-day orbit that no spacecraft has ever occupied before.
This orbit will take TESS as close to Earth as 67,000 miles (108,000 kilometers) and as far away as 232,000 miles (373,000 km). The satellite will be able to beam its onboard data down to Earth quickly and efficiently during the close approaches. 
The orbit is also incredibly stable and features relatively low radiation exposure and low thermal variation, said Robert Lockwood, TESS spacecraft program manager at Orbital ATK, the Virginia-based company that built the satellite for NASA.
"It really is a Goldilocks orbit," Lockwood told Space.com.
But TESS won't get there for a while. After a number of engine firings and one dramatic maneuver — a close flyby of the moon on May 17 — TESS will arrive in its final orbit in mid-June, if all goes according to plan. The science campaign will start shortly thereafter.
The TESS mission is capped at $200 million, not including launch costs (which added another $87 million, NASA officials said).)

Taking Direct Pictures of Exoplanets May Not Be Out of The Realm for Ground Based Telescopes.

The world's most advanced camera aims to image habitable exoplanets

Astronomers have put significant time and effort toward identifying habitable exoplanets, and with new technology emerging, it looks like their hard work could pay off sooner rather than later. NASA's Transiting Exoplanet Survey Satellite (TESS), a mission expected to identify thousands of exoplanet candidates, is scheduled for launch within the next few weeks, and the exoplanet-hunting James Webb Space Telescope is set to launch in 2020.
From article, (a new technology could soon be added to the planetary pursuit: the world’s largest and most advanced camera.
Developed by an international team of researchers, the DARK-speckle Near-infrared Energy-resolved Superconducting Spectrophotometer (DARKNESS) is a 10,000-pixel integral field spectrograph that’s able to differentiate between light emitted by planets and light emitted by stars.
“Taking a picture of an exoplanet is extremely challenging because the star is much brighter than the planet, and the planet is very close to the star,” said lead researcher Benjamin Mazin, a physicist at the University of California Santa Barbara, in a news release.
DARKNESS, which is designed to fit the 200-inch Hale telescope at the Palomar Observatory in California, functions as a focal-plane wave-front sensor as well as a camera. The sensor measures the light from planets and stars fast enough to adjust its light-collecting mirror 2,000 times per second, which allows it to counteract atmospheric distortions and create higher contrast ratios between the two light sources. Its accuracy at this rate is quite impressive, too. Even at the equivalent of thousands of frames per second, the camera doesn’t produce any read noise, which is generated when the charge from pixels is sent to the camera. It also does not produce any dark current, which is noise caused by thermal electrons falling on pixels in the absence of light. These noise factors are common causes of photographic errors and inaccuracies.
DARKNESS also uses Microwave Kinetic Inductance Detectors to establish the arrival time and wavelength of each photon detected by the camera. Determining the photons’ arrival time enables researchers to differentiate planetary light from “speckles” — scattered light from a star that could be mistaken for a planet.
“This technology will lower the contrast floor so that we can detect fainter planets,” said Mazin. “We hope to approach the photon noise limit, which will give us contrast ratios close to 10-8, allowing us to see planets 100 million times fainter than the star. At those contrast levels, we can see some planets in reflected light, which opens up a whole new domain of planets to explore. The really exciting thing is that this is a technology pathfinder for the next generation of telescopes.”
The research team is still working out some kinks with DARKNESS, but they’re continually testing its capabilities and working toward improving its contrast ratio.
“Our hope is that one day we will be able to build an instrument for the Thirty Meter Telescope planned for Mauna Kea on the island of Hawaii or La Palma,” said Mazin. “With that, we’ll be able to take pictures of planets in the habitable zones of nearby low mass stars and look for life in their atmospheres. That’s the long-term goal and this is an important step toward that.”)
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